The Best Acetaminophen 2025

Updated On April 16th, 2025

Looking for the best Acetaminophen? You aren't short of choices in 2022. The difficult bit is deciding the best Acetaminophen for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Acetaminophen.

Rank Product Name Score
1
McNeil Tylenol PM Pain Reliever/Nighttime Sleep Aid, 24 ea

McNeil Tylenol PM Pain Reliever/Nighttime Sleep Aid, 24 ea

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100%
2
Excedrin Extra Strength Pain Reliever Caplets 24 Caplets

Excedrin Extra Strength Pain Reliever Caplets 24 Caplets

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98%
3
Aspirin Regimen Bayer Low Dose Pain Reliever Enteric Coated Tablets, 81mg, 32 Count

Aspirin Regimen Bayer Low Dose Pain Reliever Enteric Coated Tablets, 81mg, 32 Count

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96%
4
Bayer Chewable Aspirin Regimen Low Dose Pain Reliever Tablets, 81mg, Orange, 108 Count

Bayer Chewable Aspirin Regimen Low Dose Pain Reliever Tablets, 81mg, Orange, 108 Count

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96%
5
Bayer Low Dose Chewable 81mg Aspirin Tablets, Orange, 36 Count

Bayer Low Dose Chewable 81mg Aspirin Tablets, Orange, 36 Count

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96%
6
Bayer Chewable Aspirin Regimen Low Dose Pain Reliever Tablets, 81mg, Cherry, 36 Count

Bayer Chewable Aspirin Regimen Low Dose Pain Reliever Tablets, 81mg, Cherry, 36 Count

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96%
7
Aleve Pain Reliever/Fever Reducer Naproxen Sodium Caplets, 220 mg, 200 Ct

Aleve Pain Reliever/Fever Reducer Naproxen Sodium Caplets, 220 mg, 200 Ct

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94%
8
Aleve Pain Reliever/Fever Reducer Naproxen Sodium Caplets, 220 mg, 100 Ct

Aleve Pain Reliever/Fever Reducer Naproxen Sodium Caplets, 220 mg, 100 Ct

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94%
9
McNeil Tylenol PM Pain Reliever/Nighttime Sleep Aid, 24 ea

McNeil Tylenol PM Pain Reliever/Nighttime Sleep Aid, 24 ea

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0%
10
Excedrin PM: PM Caplets Pain Reliever/Nighttime Sleep-Aid, 24 Ct

Excedrin PM: PM Caplets Pain Reliever/Nighttime Sleep-Aid, 24 Ct

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0%

1. McNeil Tylenol PM Pain Reliever/Nighttime Sleep Aid, 24 ea

McNeil Tylenol PM Pain Reliever/Nighttime Sleep Aid, 24 ea
100%

Our Score

Pain Reliever/Nighttime Sleep Aid, Extra Strength, Geltabs 24 geltabs Contains Acetaminophen, Diphenhydramine HCl. Non-habit forming. Geltabs (Gelatin-coated tablets). Contains no aspirin. Temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness. Do not take more than directed (see overdose warning). Adults and Children 12 Years and Over: Take 2 Geltabs at bedtime; Do not take more than 8 geltabs in 24 hours. Children Under 12 Years: Do not use this adult product in children under 12 years of age; this will provide more than the recommended dose (overdose) and may cause liver damage. Store between 20-25 degrees C (68-77 degrees F). Avoid high humidity. Alcohol Warning: If you consume 3 or more alcoholic drinks every day, ask your doctor whether you should take acetaminophen or other pain relievers or fever reducers. Acetaminophen may cause liver damage. Do not use with any other product containing acetaminophen; with any other product containing diphenhydramine, even one used on skin; in children under 12 years of age. Ask a doctor before use if you have a breathing problem such as emphysema or chronic bronchitis; trouble urinating due to an enlarged prostate gland; glaucoma. Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers. When using this product drowsiness will occur; avoid alcoholic drinks; do not drive a motor vehicle or operate machinery. Stop use and ask a doctor if sleeplessness persists continually for more than 2 weeks. Insomnia may be a symptom of serious underlying medical illness; pain gets worse or lasts more than 10 days; fever gets worse or lasts more than 3 days; redness or swelling is present; new symptoms occur. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Overdose Warning: Taking more than the recommended dose (overdose) may cause liver damage. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms. Do not use if carton is opened or neck wrap or foil inner seal imprinted Safety Seal is broken or missing. 24 geltabs Fort Washington, PA 19034 877-895-3665 MCN-PPC, Inc. '06

24 geltabs

2. Excedrin Extra Strength Pain Reliever Caplets 24 Caplets

Excedrin Extra Strength Pain Reliever Caplets 24 Caplets
98%

Our Score

Excedrin Extra Strength Pain Reliever Caplets 24 caplets

One bottle of 24 Excedrin Extra Strength Pain Relief Caplets Extra strength pain reliever that relieves pain associated with headache, colds, menstrual cramps, toothaches, muscular aches and arthritis Pain medicine for adults that is a clinically proven headache pain reliever Excedrin Extra Strength caplets contain two pain fighters and a booster for enhanced effect Pain reliever available in convenient caplet form For some, headache relief can start in 15 minutes

3. Aspirin Regimen Bayer Low Dose Pain Reliever Enteric Coated Tablets, 81mg, 32 Count

Aspirin Regimen Bayer Low Dose Pain Reliever Enteric Coated Tablets, 81mg, 32 Count
96%

Our Score

Bayer Aspirin Low Dose Chewable Tablets can help protect your heart by helping to prevent a second heart attack when taken as directed by your doctor. Aspirin is not appropriate for everyone, so be sure to talk to your doctor before you begin an aspirin regimen. Each low dose aspirin tablet contains 81 mg aspirin and can be taken to help reduce the chance of a second heart attack by 31%. With 81 mg of low dose aspirin per tablet, Bayer Aspirin Low Dose Chewable Tablets are made for adults to help prevent another heart attack or ischemic stroke. Conveniently chewable for those who have troubleswallowing, each 81mg aspirin tablet is also caffeine and sodium-free. Bayer Aspirin also provides relief of minor body aches and pains. When taking for pain, take 4 to 8 tablets every 4 hours with a full glass of water. Do not exceed 48 tablets in 24 hours. Use as directed.

81mg Aspirin can also be taken for temporary relief of minor body aches and pains Helps prevent a second heart attack by 31% and another ischemic stroke by 25 Made for adults who have difficulty swallowing pills These low dose aspirin chewable tablets are sodium and caffeine-free When taking for pain, take 4 to 8 tablets every 4 hours with a full glass of water. Do not exceed 48 tablets in 24 hours Bayer Aspirin has been a leading brand for second cardiovascular prevention Bayer Aspirin Low Dose 81 mg Chewable Tablets, Pain Reliever, Orange Flavored, 32 Tablets

4. Bayer Chewable Aspirin Regimen Low Dose Pain Reliever Tablets, 81mg, Orange, 108 Count

Bayer Chewable Aspirin Regimen Low Dose Pain Reliever Tablets, 81mg, Orange, 108 Count
96%

Our Score

Bayer Aspirin Low Dose Chewable Tablets can help protect your heart by helping to prevent a second heart attack when taken as directed by your doctor. Aspirin is not appropriate for everyone, so be sure to talk to your doctor before you begin an aspirin regimen. Each low dose aspirin tablet contains 81 mg aspirin and can be taken to help reduce the chance of a second heart attack by 31%. With 81 mg of low dose aspirin per tablet, Bayer Aspirin Low Dose Chewable Tablets are made for adults to help prevent another heart attack or ischemic stroke. Conveniently chewable for those who have trouble swallowing, each 81mg aspirin tablet is also caffeine and sodium-free. Bayer Aspirin also provides relief of minor body aches and pains. When taking for pain, take 4 to 8 tablets every 4 hours with a full glass of water. Do not exceed 48 tablets in 24 hours. It is always advisable to speak to your doctor about individual dosing. Use as directed.

81mg aspirin can also be taken for temporary relief of minor body aches and pains Made for adults to help prevent another heart attack or ischemic stroke, these chewable tablets are sodium and caffeine-free Aspirin is not appropriate for everyone, so be sure to talk to your doctor before you begin an aspirin regimen Chewable low dose aspirin tablets for those who have difficulty swallowing pills When taking for pain, take 4 to 8 tablets every 4 hours with a full glass of water. Do not exceed 48 tablets in 24 hours Bayer Aspirin has been a leading brand for second cardiovascular prevention Bayer Aspirin Low Dose 81 mg Chewables, Pain Reliever, Orange Flavored, 36 Tablets (Pack of 3)

5. Bayer Low Dose Chewable 81mg Aspirin Tablets, Orange, 36 Count

Bayer Low Dose Chewable 81mg Aspirin Tablets, Orange, 36 Count
96%

Our Score

Bayer Chewable Aspirin 81mg Tablets are low dose aspirin tablets made especially for adults who may have trouble swallowing pills. When taken under a doctor's direction, Bayer 81mg aspirin tablets are recommended to help reduce the risk of another heart attack or clot-related (ischemic) stroke.* Aspirin is proven to reduce the risk of another heart attack by 31% and to reduce the risk of another ischemic stroke by 22%. This caffeine-free and sodium-free pain chewable tablet features a pleasant orange flavor, making it easy to take. Use Bayer aspirin as directed for secondary prevention against another heart attack or clot-related stroke. Trust Bayer, the #1 doctor recommended aspirin brand, to help ensure you are there with the people who love you. *Aspirin is not appropriate for everyone, so be sure to talk to your doctor before you begin an aspirin regimen.

Bayer Chewable Aspirin Regimen Low Dose Pain Reliever Tablets, 81mg, Orange, 36 Ct: Helps prevent another heart attack or clot-related (ischemic) stroke when taken as directed by your doctor Chewable, for those who may have difficulty swallowing pills Is available in pleasant cherry and orange flavored aspirin tablets Aspirin is not appropriate for everyone, so be sure to talk to your doctor before you begin an aspirin regimen Is sodium- and caffeine-free

6. Bayer Chewable Aspirin Regimen Low Dose Pain Reliever Tablets, 81mg, Cherry, 36 Count

Bayer Chewable Aspirin Regimen Low Dose Pain Reliever Tablets, 81mg, Cherry, 36 Count
96%

Our Score

Bayer Aspirin Low Dose Chewable Tablets can help protect your heart by helping to prevent a second heart attack when taken as directed by your doctor. Aspirin is not appropriate for everyone, so be sure to talk to your doctor before you begin an aspirin regimen. Each low dose aspirin tablet contains 81 mg aspirin and can be taken to help reduce the chance of a second heart attack by 31%. With 81 mg of low dose aspirin per tablet, Bayer Aspirin Low Dose Chewable Tablets are made for adults to help prevent another heart attack or ischemic stroke. Conveniently chewable for those who have trouble swallowing, each 81mg aspirin tablet is also caffeine and sodium-free. Bayer Aspirin also provides relief of minor body aches and pains. When taking for pain, take 4 to 8 tablets every 4 hours with a full glass of water. Do not exceed 48 tablets in 24 hours. Use as directed.

81mg Aspirin can also be taken for temporary relief of minor body aches and pains Helps prevent a second heart attack by 31% and another ischemic stroke by 22% Made for adults who have difficulty swallowing pills These low dose aspirin chewable tablets are sodium and caffeine-free When taking for pain, take 4 to 8 tablets every 4 hours with a full glass of water. Do not exceed 48 tablets in 24 hours Bayer Aspirin has been a leading brand for second cardiovascular prevention Bayer Aspirin Low Dose 81 mg Chewable Tablets, Pain Reliever, Cherry Flavored, 36 Tablets

7. Aleve Pain Reliever/Fever Reducer Naproxen Sodium Caplets, 220 mg, 200 Ct

Aleve Pain Reliever/Fever Reducer Naproxen Sodium Caplets, 220 mg, 200 Ct
94%

Our Score

When you're tired of taking and retaking pills every few hours to deal with long-lasting aches and pains, Aleve can help. Just 1 caplet is strong enough to provide pain relief that can last up to 12 hours, which means no more stopping throughout the day to take more caplets. Aleve is an over-the-counter (OTC), nonsteroidal anti-inflammatory drug (NSAID) that provides temporary relief from minor aches and pains. It also temporarily reduces fever.

Aleve Pain Reliever/Fever Reducer Naproxen Sodium Caplets, 220 mg, 200 Ct Aleve is Proven Better and Lasts Longer on Pain than Tylenol Only Aleve Works at the Site of Pain All Day with Just Two Pills. Aleve is different, unlike Tylenol and Advil, each Aleve caplet has the strength to last 12 hours Aleve is an over-the-counter (OTC), nonsteroidal anti-inflammatory drug (NSAID) designed to deliver continuous pain relief at the site of pain For 25 years, Aleve has provided temporary relief of minor aches and pains due to backaches, muscular aches, headaches, minor arthritis and other joint pain, menstrual pain, toothaches, and the common cold. Also temporarily reduces fever Data on file. Based on minimum labeled dosing

8. Aleve Pain Reliever/Fever Reducer Naproxen Sodium Caplets, 220 mg, 100 Ct

Aleve Pain Reliever/Fever Reducer Naproxen Sodium Caplets, 220 mg, 100 Ct
94%

Our Score

When you're tired of taking and retaking pills every few hours to deal with long-lasting aches and pains, Aleve can help. Just 1 caplet is strong enough to provide pain relief that can last up to 12 hours, which means no more stopping throughout the day to take more caplets. Aleve is different, unlike Tylenol (Acetaminophen) and Advil (ibuprofen), each Aleve caplet has the strength to last 12 hours. Aleve is an over-the-counter (OTC), nonsteroidal anti-inflammatory drug (NSAID) that provides temporary relief from minor aches and pains. It also temporarily reduces fever and provides headache relief.

Aleve is Proven Better* and Lasts Longer** on Pain than Tylenol. Only Aleve Works at the Site of Pain All Day with Just Two Pills. Aleve is different, unlike Tylenol (Acetaminophen) and Advil (ibuprofen), each Aleve caplet has the strength to last 12 hours.** Aleve is the #1 Orthopedic Surgeon Recommended OTC brand for minor arthritis pain. Aleve is an over-the-counter (OTC), nonsteroidal anti-inflammatory drug (NSAID) designed to deliver continuous pain relief at the site of pain. For 25 years, Aleve has provided temporary relief of minor aches and pains due to backaches, muscular aches, headaches, minor arthritis and other joint pain, menstrual pain, toothaches, and the common cold. Also temporarily reduces fever and provides heacahe relief. *Data on file. **Based on minimum labeled dosing.

9. McNeil Tylenol PM Pain Reliever/Nighttime Sleep Aid, 24 ea

McNeil Tylenol PM Pain Reliever/Nighttime Sleep Aid, 24 ea
0%

Our Score

Pain Reliever/Nighttime Sleep Aid, Extra Strength, Caplets 24 caplets Contains acetaminophen, Diphenhydramine HCl. Non-habit forming. Contains no aspirin. Temporary relief of occasional headaches and minor aches and pains with accompanying sleeplessness. Do not take more than directed (see overdose warning). Adults and Children 12 Years and Over: Take 2 caplets at bedtime. Do not take more than 8 caplets in 24 hours. Children Under 12 Years: Do not use this adult product in children under 12 years of age. This will provide more than the recommended dose (overdose), and may cause liver damage. Store between 68-77 degrees F (20-25 degrees C). Alcohol Warning: If you consume 3 or more alcoholic drinks every day, ask your doctor whether you should take acetaminophen or other pain relievers or fever reducers. Acetaminophen may cause liver damage. Do not use: with any other product containing acetaminophen; with any other product containing diphenhydramine, even one used on skin; in children under 12 years of age. Ask a doctor before use if you have: a breathing problem such as emphysema or chronic bronchitis; trouble urinating due to an enlarged prostate gland; glaucoma. Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers. When using this product: drowsiness will occur; avoid alcoholic drinks; do not drive a motor vehicle or operate machinery. Stop use and ask a doctor if: sleeplessness persists continuously for more than 2 weeks. Insomnia may be a symptom of a serious underlying medical illness; pain gets worse or lasts more than 10 days; fever gets worse or lasts more than 3 days; redness or swelling is present; new symptoms occur. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Overdose Warning: Taking more than the recommended dose (overdose) may cause liver damage. In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms. Do not use if the carton is opened or neck wrap or foil inner seal imprinted with Safety Seal is broken. 24 caplets Fort Washington, PA 19034 877-TYLENOL MCN-PPC, Inc. '06

Non-habit FORMING TEMPORARILY relief Of occasional headaches And minor aches And pains with accompanying sleeplessness.

10. Excedrin PM: PM Caplets Pain Reliever/Nighttime Sleep-Aid, 24 Ct

Excedrin PM: PM Caplets Pain Reliever/Nighttime Sleep-Aid, 24 Ct
0%

Our Score

Excedrin PM Caplets will help to relieve pain while also helping you get a good rest for the night. This product is aspirin-free and has the active ingredients of acetaminophen and diphenhydramine. This nighttime sleep aid, 24-count is non-habit forming.Excedrin PM Caplets Pain Reliever Nighttime Sleep-Aid, 24-Count:

Stops pain Aspirin-free Excedrin pain reliever


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