The Best Diphenhydramine 2025

Updated On April 5th, 2025

Looking for the best Diphenhydramine? You aren't short of choices in 2022. The difficult bit is deciding the best Diphenhydramine for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Diphenhydramine.

Rank Product Name Score
1
Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle

Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle

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100%
2
Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle

Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle

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100%
3
KS Allergy Medicine Diphenhydramine HCI 25 Mg 600 Tablets (Pack of 3)

KS Allergy Medicine Diphenhydramine HCI 25 Mg 600 Tablets (Pack of 3)

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100%
4
Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets

Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets

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98%
5
Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.

Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.

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98%
6
Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 Mg, 100 Count

Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 Mg, 100 Count

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92%
7
KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack

KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack

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90%
8
GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies

GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itch

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80%
9
Leader Children’s Allergy Relief Liquid, Diphenhydramine HCL 12.5 mg / 5m Oral Solution, Antihistamine, Cherry Flavor, Alcohol Free, 4 fl oz

Leader Children’s Allergy Relief Liquid, Diphenhydramine HCL 12.5 mg / 5m Oral Solution, Antihistamine, Cherry Flavor, Alcohol F

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0%
10
Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count

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0%

1. Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle

Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle
100%

Our Score

Major Allergy Relief Diphenhydramine HCl Capsule, 100 per Bottle Diphenhydramine temporarily relieves symptoms caused by hay fever or other upper respiratory allergies: runny nose; sneezing; itchy, watery eyes; itching of the nose or throat. One of the most effective over-the-counter antihistamines, diphenhydramine is the generic version of Benadryl. Diphenhydramine can also be used to prevent and treat nausea, vomiting and dizziness caused by motion sickness. Like Benadryl, these diphenhydramine tablets will likely cause drowsiness. 1 Bottle(s), 100 Allergy Relief Bottle , 100 Total Count

There are 50 milligrams of diphenhydramine HCl in a capsule Compare to active ingredient in Benadryl® Extra Strength Allergy Relief Ultratabs® – a registered trademark of Kenvue Antihistamine is not a nondrowsy type so it is recommended you take before bedtime There are 100 capsules in a bottle

2. Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle

Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle
100%

Our Score

Geri-Care Allergy Relief 25 mg Diphenhydramine HCl Tablet, 1,000 per Bottle Get effective relief from your allergies with Geri-Care Diphenhydramine Allergy Relief – antihistamine relief in a small tablet that works against the most powerful allergens. Diphenhydramine will also mitigate symptoms of motion sickness 1 Bottle(s), 1000 Allergy Relief Bottle , 1000 Total Count

Antihistamine 25 mg diphenhydramine hydrochloride per tablet Compare to active ingredient in Benadryl® Allergy Ultratab® – a registered trademark of Kenvue. 1,000 ultra-small tablets per bottle

3. KS Allergy Medicine Diphenhydramine HCI 25 Mg 600 Tablets (Pack of 3)

KS Allergy Medicine Diphenhydramine HCI 25 Mg 600 Tablets (Pack of 3)
100%

Our Score

This allergy medicine temporarily relieves symptoms such as runny nose, sneezing, itching, watery eyes, and itching of the nose or throat. Please note that when using this product, marked drowsiness may occur. Excitability may also occur, especially in children

Diphenhydramine HCl 25 mg is for antihistamine and allergy relief. Temporarily relieves symptoms such as sneezing, itching, watery eyes, and itching of the nose or throat. It also relieves symptoms due to the common cold, such as runny nose and sneezing. This temporarily relieves symptoms from hay fever and upper respiratory allergies. Do not use with any other product containing diphenhydramine, even one used on skin.

4. Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets

Member's Mark Diphenhydramine HCI 25 mg Antihistamine for Allergy Relief - 600 Tablets
98%

Our Score

Members Mark Diphenhydramine Antihistamine Tablets is used for the temporary relief of these symptoms due to hay fever or other upper respiratory allergies: runny nose, sneezing, itchy, watery eyes, itching of the nose or throat. Members Mark is dedicated providing healthful, gentle, and safe personal care products for the entire family. We continuously strive to be your partner in wellness and exceed your expectations.

Uses: Temporarily relieves symptoms from hay fever and upper respiratory allergies: Runny Nose, Sneezing, Itching, watery eyes, Itching of the nose or throat Active Ingredients (in each tablet) - Purpose: Diphenhydramine HCl 25 mg - Antihistamine. Warnings. Do not use: To make a child sleepy. With any other product containing diphenhydramine, even one used on skin.

5. Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.

Berkley Jensen 25mg Diphenhydramine Hydrochloride Antihistamine Cold & Allergy Relief Tablets, 400 ct.
98%

Our Score

These antihistamine tablets are designed to temporarily relieve upper respiratory symptoms caused by allergies or the common cold. The tablets are easy to swallow for convenient relief. Product Features: For relief of sneezing, itchy, watery eyes, runny nose and itchy throat caused by allergies or the common cold Tablets are easy to swallow Adults take 1 or 2 tablets every 4 ' 6 hours; do not take more than 6 doses in 24 hours Product Warnings: Ask a doctor before use if you have glaucoma, trouble urinating due to an enlarged prostate gland or a breathing problem such as emphysema or chronic bronchitis When using this product, marked drowsiness may occur and excitability may occur, especially in children Avoid alcoholic drinks. Alcohol, sedatives and tranquilizers may increase drowsiness.

These antihistamine tablets are designed to temporarily relieve upper respiratory symptoms caused by allergies or the common cold. The tablets are easy to swallow for convenient relief.Product Features:For relief of sneezing, itchy, watery eyes, runny nose and itchy throat caused by allergies or the

6. Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 Mg, 100 Count

Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 Mg, 100 Count
92%

Our Score

Formulated with the powerful diphenhydramine as the primary aCountive ingredient, this medication relieves common allergy symptoms such as runny nose, itchy eyes, and sneezing. Santo Remedio Para Diphenhydramine Allergy Relief Tablets are a springtime staple for temporary allergy symptom relief. Each tablet is a small, easy to swallow size for adults and children over 12 years old. Allergies can come at unexpected times and in unexpected places. This non-drowsy formulation gives you the relief you need without unforeseen consequences.

Santo Remedio Diphenhydramine Allergy Relief Tablets, 25 Mg, 100 Count: Santo Remedio Diphenhydramine Allergy Relief Tablets are made to relieve allergy symptoms Alleviates runny nose, itchy eyes, and sneezing, so you can get back to enjoying your day Easy to store in your medicine cabinet, desk, car, and purse Take 1 caplet every 4-6 hours while symptoms persist All ingredients have been tested to ensure true identity, purity, and strength Each bottle contains 100 tablets with standard 25 Mg of diphenhydramine per tablet Santo Remedio is a complete and natural range of health produCounts developed by renowned physician Dr. Juan Rivera

7. KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack

KS Allergy Medicine Diphenhydramine HCI 25 mg 600 Tablets 2 pack
90%

Our Score

This allergy medicine temporarily relieves symptoms such as runny nose, sneezing, itching, watery eyes, and itching of the nose or throat. Please note that when using this product, marked drowsiness may occur. Excitability may also occur, especially in children

Diphenhydramine HCl 25 mg is for antihistamine and allergy relief. Temporarily relieves symptoms such as sneezing, itching, watery eyes, and itching of the nose or throat. It also relieves symptoms due to the common cold, such as runny nose and sneezing. This temporarily relieves symptoms from hay fever and upper respiratory allergies. Do not use with any other product containing diphenhydramine, even one used on skin.

8. GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies

GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies
80%

Our Score

✅ BULK SAVINGS BOTTLE - Stop worrying about constant refills or late night allergy attacks with no pills on hand. Our 1000 count bottle is the perfect size for families or people who suffer from chronic indoor and outdoor allergies. Easy to swallow tablet ✅ ITCHY EYE RELIEF - Experience fast relief from itchy, puffy, red or watery eyes typically caused by pet dander, hair, pollen, dust and hay fever. You don't have to suffer through allergy symptoms another day longer. Itchy eyes can negatively affect your vision, focus and even work performance. ✅ BETTER BREATHING - Diphenhydramine HCL helps reduce and relieve congestion of your nose, sinus and throat to help you breathe better and deeper. The antihistamine effects of this over the counter medication can help reduce the symptoms of the common cold like a runny nose, coughing or sneezing. ✅ MORE RESTFUL SLEEP - Allergy symptoms can make your whole day miserable, but they can also affect your sleep. The antihistamine response may naturally cause drowsiness in both adults and kids, so it is often taken in the evening or before bed to help you fall asleep faster and stay asleep. ✅ 100% SATISFACTION GUARANTEE - We know you and your family will love the ultimate convenience of our 1000 count bulk savings bottle. That's why we back up each tamper proof bottle with our 100% Satisfaction Guarantee. Join thousands of allergy symptom free customers...Click Add-to-Cart Today!

GenCare - Allergy Relief Medicine | Antihistamine Diphenhydramine HCl 25mg (1000 Tablets Per Bottle) Value Pack | Relieve for Itchy Eyes, Sneezing, Runny Nose | Seasonal or Indoor & Outdoor Allergies

9. Leader Children’s Allergy Relief Liquid, Diphenhydramine HCL 12.5 mg / 5m Oral Solution, Antihistamine, Cherry Flavor, Alcohol Free, 4 fl oz

Leader Children’s Allergy Relief Liquid, Diphenhydramine HCL 12.5 mg / 5m Oral Solution, Antihistamine, Cherry Flavor, Alcohol Free, 4 fl oz
0%

Our Score

LEADER Kids Allergy Medicine provides relief from multiple symptoms at the same time like runny nose, sneezing, itchy watery eyes, itching of the nose or throat, associated with seasonal allergies or hay fever. LEADER Children's Allergy Medicine has an alcohol-free formula that is safe for young kids to consume without adverse side effects. Please bear in mind some drowsiness may occur when using this item. Do not combine with other Diphenhydramine products, even on skin. LEADER Diphenhydramine Liquid provides a respite from allergies for 4-6 hours, when taken as directed on the package. Use only enclosed dosing cap specifically designed for this item. Do not use another dosing device. Active ingredient (in each 5 mL): Diphenhydramine HCl 12.5 mg. NDC Code(s): 70000-0474-1

TARGET MULTIPLE SYMPTOMS: LEADER Kids Allergy Medicine provides relief from multiple symptoms at the same time like runny nose, sneezing, itchy watery eyes, itching of the nose or throat, associated with seasonal allergies or hay fever. ALCOHOL-FREE: LEADER Children's Allergy Medicine has an alcohol-free formula that is safe for young kids to consume without adverse side effects. Please bear in mind some drowsiness may occur when using this item. Do not combine with other Diphenhydramine products, even on the skin. 4-6 HOURS OF ALLERGY RELIEF: LEADER Diphenhydramine Liquid provides a respite from allergies for 4-6 hours when taken as directed on the package. Use only the enclosed dosing cap specifically designed for this item. Do not use another dosing device. Please read the instructions carefully before ingesting. CHERRY FLAVOR: LEADER Diphenhydramine Liquid Kids comes in a kid-friendly cherry flavor, which even the pickiest little ones won’t detect its medicine. Available in Bubble Gum flavor as well. Certified Gluten Free. Do not use it to make a child sleepy. SAFE FOR KIDS 6-11: LEADER Liquid Benadryl Kids Generic is suitable for kids ages 6 to 11. Administer 5-10 ml every 4 to 6 hours. Do not use on children ages 2-5 unless directed by a doctor. Not intended for young infants. If any allergies occur please discontinue application immediately.

10. Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg, 6 Count
0%

Our Score

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg., 6 Count

Lil' Drug Store Allergy Diphenhydramine HCI Antihistamine Tablets, 25 mg., 6 Count


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