The Best Prilosec 2025

Updated On April 6th, 2025

Looking for the best Prilosec? You aren't short of choices in 2022. The difficult bit is deciding the best Prilosec for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Prilosec.

Rank Product Name Score
1
Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 28 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 28 Count

Check Price
96%
2
Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 42 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 42 Count

Check Price
96%
3
Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Wildberry, 42 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Wildberry, 42 Count

Check Price
96%
4
Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 14 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 14 Count

Check Price
94%
5
Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Wildberry, 14 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Wildberry, 14 Count

Check Price
94%
6
Prilosec 42ct W/superbowl Dvd Brown Case

Prilosec 42ct W/superbowl Dvd Brown Case

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0%
7
Prilosec 14ct W/nascar Track Pass

Prilosec 14ct W/nascar Track Pass

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0%
8
Prilosec 11pc Prilo Pepto Pdq

Prilosec 11pc Prilo Pepto Pdq

Check Price
0%
9
Prilosec 28ct+14ct Free

Prilosec 28ct+14ct Free

Check Price
0%
10
Prilosec 10pcprilo 15in Pdq

Prilosec 10pcprilo 15in Pdq

Check Price
0%

1. Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 28 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 28 Count
96%

Our Score

With Prilosec OTC Omeprazole 20mg Unflavored Tablets 28ct, you can take control of heartburn. If you suffer from frequent heartburn, there’s no need to stash antacids everywhere for whenever heartburn might strike. With Prilosec OTC, you can take 1 PILL A DAY for 24 HOURS of ZERO HEARTBURN.* with this 24 hour acid reducer. Prilosec OTC contains omeprazole 20mg and is the first and original over-the-counter frequent heartburn (defined as occurring 2 or more times per week) medicine. The active ingredient in Prilosec OTC is omeprazole magnesium delayed-release tablet 20mg (equivalent to 20.6mg omeprazole), which is part of a class of medications called proton pump inhibitors, or PPIs. PPIs reduce stomach acid production by shutting down many of the pumps in the stomach that produce acid. In other words, Prilosec OTC 24 hour acid reducer blocks acid production at its source, so you don’t get heartburn in the first place.* Take Prilosec OTC once a day and use as directed for 14 days to treat frequent heartburn. Prilosec OTC may take 1-4 days for full effect. Prilosec OTC is the #1 Doctor†, Gastroenterologist^ and Pharmacist^^ recommended OTC frequent heartburn medicine.*It’s possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. May take 1-4 days for full effect**Confirm with insurance provider±P&G Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16.†^IQVIA ProVoice™ Survey, Jan 2005 – Mar 2020^^Pharmacy Times Surveys, Acid Reducer/Heartburn Categories 2006-2018. For adults 18 years of age and older.

Prilosec OTC TREATS FREQUENT HEARTBURN: Prilosec OTC omeprazole 20mg heartburn medicine for those who experience heartburn 2+ times a week. With just 1 PILL each morning, experience 24 HOURS with ZERO HEARTBURN With 1 PRILOSEC OTC PILL EACH MORNING, 24 HOURS. ZERO HEARTBURN.* Unlike antacids which last only 1-3 hours PREVENT EXCESS ACID PRODUCTION for heartburn relief that lasts for 24 HOURS.* Starts working on DAY 1* CONTAINS ACTIVE INGREDIENT OMEPRAZOLE delayed-release 20mg, an acid reducer that provides long-lasting, 24-hour heartburn relief* #1 DOCTOR and GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for 15 straight years^ May be HSA and FSA eligible** OVER 30 MILLION AMERICANS have used Prilosec OTC Omeprazole 20mg pills as their frequent heartburn medicine SATISFACTION GUARANTEED or your money back For adults 18 years of age and older.

2. Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 42 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 42 Count
96%

Our Score

With Prilosec OTC Omeprazole 20mg Unflavored Tablets 42ct, you can take control of heartburn. If you suffer from frequent heartburn, there’s no need to stash antacids everywhere for whenever heartburn might strike. With Prilosec OTC, you can take 1 PILL A DAY for 24 HOURS of ZERO HEARTBURN.* with this 24 hour acid reducer. Prilosec OTC contains omeprazole 20mg and is the first and original over-the-counter frequent heartburn (defined as occurring 2 or more times per week) medicine. The active ingredient in Prilosec OTC is omeprazole magnesium delayed-release tablet 20mg (equivalent to 20.6mg omeprazole), which is part of a class of medications called proton pump inhibitors, or PPIs. PPIs reduce stomach acid production by shutting down many of the pumps in the stomach that produce acid. In other words, Prilosec OTC 24 hour acid reducer blocks acid production at its source, so you don’t get heartburn in the first place.* Take Prilosec OTC once a day and use as directed for 14 days to treat frequent heartburn. Prilosec OTC may take 1-4 days for full effect. Prilosec OTC is the #1 Doctor†, Gastroenterologist^ and Pharmacist^^ recommended OTC frequent heartburn medicine.*It’s possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. May take 1-4 days for full effect**Confirm with insurance provider±P&G Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16.†^IQVIA ProVoice™ Survey, Jan 2005 – Mar 2020^^Pharmacy Times Surveys, Acid Reducer/Heartburn Categories 2006-2018. For adults 18 years of age and older.

Prilosec OTC TREATS FREQUENT HEARTBURN: Prilosec OTC omeprazole 20mg heartburn medicine for those who experience heartburn 2+ times a week. With just 1 PILL each morning, experience 24 HOURS with ZERO HEARTBURN With 1 PRILOSEC OTC PILL EACH MORNING, 24 HOURS. ZERO HEARTBURN.* Unlike antacids which last only 1-3 hours PREVENT EXCESS ACID PRODUCTION for heartburn relief that lasts for 24 HOURS.* Starts working on DAY 1* CONTAINS ACTIVE INGREDIENT OMEPRAZOLE delayed-release 20mg, an acid reducer that provides long-lasting, 24-hour heartburn relief* #1 DOCTOR and GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for 15 straight years^ May be HSA and FSA eligible** OVER 30 MILLION AMERICANS have used Prilosec OTC Omeprazole 20mg pills as their frequent heartburn medicine SATISFACTION GUARANTEED or your money back For adults 18 years of age and older.

3. Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Wildberry, 42 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Wildberry, 42 Count
96%

Our Score

With Prilosec OTC Omeprazole 20mg Wildberry Tablets 42ct, you can take control of heartburn. If you suffer from frequent heartburn, there’s no need to stash antacids everywhere for whenever heartburn might strike. With Prilosec OTC, you can take 1 PILL A DAY for 24 HOURS of ZERO HEARTBURN.* with this 24 hour acid reducer. Prilosec OTC contains omeprazole 20mg and is the first and original over-the-counter frequent heartburn (defined as occurring 2 or more times per week) medicine. The active ingredient in Prilosec OTC is omeprazole magnesium delayed-release tablet 20mg (equivalent to 20.6mg omeprazole), which is part of a class of medications called proton pump inhibitors, or PPIs. PPIs reduce stomach acid production by shutting down many of the pumps in the stomach that produce acid. In other words, Prilosec OTC 24 hour acid reducer blocks acid production at its source, so you don’t get heartburn in the first place.* Take Prilosec OTC once a day and use as directed for 14 days to treat frequent heartburn. Prilosec OTC may take 1-4 days for full effect. Prilosec OTC is the #1 Doctor†, Gastroenterologist^ and Pharmacist^^ recommended OTC frequent heartburn medicine.*It’s possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. May take 1-4 days for full effect**Confirm with insurance provider±P&G Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16.†^IQVIA ProVoice™ Survey, Jan 2005 – Mar 2020^^Pharmacy Times Surveys, Acid Reducer/Heartburn Categories 2006-2018. For adults 18 years of age and older.

Prilosec OTC TREATS FREQUENT HEARTBURN: Prilosec OTC omeprazole 20mg heartburn medicine for those who experience heartburn 2+ times a week. With just 1 PILL each morning, experience 24 HOURS with ZERO HEARTBURN With 1 PRILOSEC OTC PILL EACH MORNING, 24 HOURS. ZERO HEARTBURN.* Unlike antacids which last only 1-3 hours PREVENT EXCESS ACID PRODUCTION for heartburn relief that lasts for 24 HOURS.* Starts working on DAY 1* CONTAINS ACTIVE INGREDIENT OMEPRAZOLE delayed-release 20mg, an acid reducer that provides long-lasting, 24-hour heartburn relief* #1 DOCTOR and GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for 15 straight years^ May be HSA and FSA eligible** OVER 30 MILLION AMERICANS have used Prilosec OTC Omeprazole 20mg pills as their frequent heartburn medicine SATISFACTION GUARANTEED or your money back For adults 18 years of age and older.

4. Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 14 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 14 Count
94%

Our Score

With Prilosec OTC Omeprazole 20mg Unflavored Tablets 14ct, you can take control of heartburn. If you suffer from frequent heartburn, there’s no need to stash antacids everywhere for whenever heartburn might strike. With Prilosec OTC, you can take 1 PILL A DAY for 24 HOURS of ZERO HEARTBURN.* with this 24 hour acid reducer. Prilosec OTC contains omeprazole 20mg and is the first and original over-the-counter frequent heartburn (defined as occurring 2 or more times per week) medicine. The active ingredient in Prilosec OTC is omeprazole magnesium delayed-release tablet 20mg (equivalent to 20.6mg omeprazole), which is part of a class of medications called proton pump inhibitors, or PPIs. PPIs reduce stomach acid production by shutting down many of the pumps in the stomach that produce acid. In other words, Prilosec OTC 24 hour acid reducer blocks acid production at its source, so you don’t get heartburn in the first place.* Take Prilosec OTC once a day and use as directed for 14 days to treat frequent heartburn. Prilosec OTC may take 1-4 days for full effect. Prilosec OTC is the #1 Doctor†, Gastroenterologist^ and Pharmacist^^ recommended OTC frequent heartburn medicine.*It’s possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. May take 1-4 days for full effect**Confirm with insurance provider±P&G Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16.†^IQVIA ProVoice™ Survey, Jan 2005 – Mar 2020^^Pharmacy Times Surveys, Acid Reducer/Heartburn Categories 2006-2018. For adults 18 years of age and older.

Prilosec OTC TREATS FREQUENT HEARTBURN: Prilosec OTC omeprazole 20mg heartburn medicine for those who experience heartburn 2+ times a week. With just 1 PILL each morning, experience 24 HOURS with ZERO HEARTBURN With 1 PRILOSEC OTC PILL EACH MORNING, 24 HOURS. ZERO HEARTBURN.* Unlike antacids which last only 1-3 hours PREVENT EXCESS ACID PRODUCTION for heartburn relief that lasts for 24 HOURS.* Starts working on DAY 1* CONTAINS ACTIVE INGREDIENT OMEPRAZOLE delayed-release 20mg, an acid reducer that provides long-lasting, 24-hour heartburn relief* #1 DOCTOR and GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for 15 straight years^ May be HSA and FSA eligible** OVER 30 MILLION AMERICANS have used Prilosec OTC Omeprazole 20mg pills as their frequent heartburn medicine SATISFACTION GUARANTEED or your money back For adults 18 years of age and older.

5. Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Wildberry, 14 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Wildberry, 14 Count
94%

Our Score

With Prilosec OTC Omeprazole 20mg Wildberry Tablets 14ct, you can take control of heartburn. If you suffer from frequent heartburn, there’s no need to stash antacids everywhere for whenever heartburn might strike. With Prilosec OTC, you can take 1 PILL A DAY for 24 HOURS of ZERO HEARTBURN.* with this 24 hour acid reducer. Prilosec OTC contains omeprazole 20mg and is the first and original over-the-counter frequent heartburn (defined as occurring 2 or more times per week) medicine. The active ingredient in Prilosec OTC is omeprazole magnesium delayed-release tablet 20mg (equivalent to 20.6mg omeprazole), which is part of a class of medications called proton pump inhibitors, or PPIs. PPIs reduce stomach acid production by shutting down many of the pumps in the stomach that produce acid. In other words, Prilosec OTC 24 hour acid reducer blocks acid production at its source, so you don’t get heartburn in the first place.* Take Prilosec OTC once a day and use as directed for 14 days to treat frequent heartburn. Prilosec OTC may take 1-4 days for full effect. Prilosec OTC is the #1 Doctor†, Gastroenterologist^ and Pharmacist^^ recommended OTC frequent heartburn medicine.*It’s possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. May take 1-4 days for full effect**Confirm with insurance provider±P&G Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16.†^IQVIA ProVoice™ Survey, Jan 2005 – Mar 2020^^Pharmacy Times Surveys, Acid Reducer/Heartburn Categories 2006-2018. For adults 18 years of age and older.

Prilosec OTC TREATS FREQUENT HEARTBURN: Prilosec OTC omeprazole 20mg heartburn medicine for those who experience heartburn 2+ times a week. With just 1 PILL each morning, experience 24 HOURS with ZERO HEARTBURN With 1 PRILOSEC OTC PILL EACH MORNING, 24 HOURS. ZERO HEARTBURN.* Unlike antacids which last only 1-3 hours PREVENT EXCESS ACID PRODUCTION for heartburn relief that lasts for 24 HOURS.* Starts working on DAY 1* CONTAINS ACTIVE INGREDIENT OMEPRAZOLE delayed-release 20mg, an acid reducer that provides long-lasting, 24-hour heartburn relief* #1 DOCTOR and GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for 15 straight years^ May be HSA and FSA eligible** OVER 30 MILLION AMERICANS have used Prilosec OTC Omeprazole 20mg pills as their frequent heartburn medicine SATISFACTION GUARANTEED or your money back For adults 18 years of age and older.

6. Prilosec 42ct W/superbowl Dvd Brown Case

Prilosec 42ct W/superbowl Dvd Brown Case
0%

Our Score

short description is not available

Prilosec 42ct W/superbowl Dvd Brown Case

7. Prilosec 14ct W/nascar Track Pass

Prilosec 14ct W/nascar Track Pass
0%

Our Score

short description is not available

Prilosec 14ct W/nascar Track Pass

8. Prilosec 11pc Prilo Pepto Pdq

Prilosec 11pc Prilo Pepto Pdq
0%

Our Score

short description is not available

Prilosec 11pc Prilo Pepto Pdq

9. Prilosec 28ct+14ct Free

Prilosec 28ct+14ct Free
0%

Our Score

short description is not available

Prilosec 28ct+14ct Free

10. Prilosec 10pcprilo 15in Pdq

Prilosec 10pcprilo 15in Pdq
0%

Our Score

short description is not available

Prilosec 10pcprilo 15in Pdq


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