The Best Prilosec 2025

Updated On January 28th, 2025

Looking for the best Prilosec? You aren't short of choices in 2022. The difficult bit is deciding the best Prilosec for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Prilosec.

Rank Product Name Score
1
Product of Prilosec OTC 20.6mg Tablets, 42 ct. - [Bulk Savings]

Product of Prilosec OTC 20.6mg Tablets, 42 ct. - [Bulk Savings]

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100%
2
Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea

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98%
3
Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 14 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 14 Count

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94%
4
20pcprilosec Otc 42

20pcprilosec Otc 42

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0%
5
14pcprilosec Otc 42

14pcprilosec Otc 42

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0%
6
Prilosec OTC 20.6mg Tablets, Omeprazole Magnesium, Acid Relief, Adults, 42 Ct

Prilosec OTC 20.6mg Tablets, Omeprazole Magnesium, Acid Relief, Adults, 42 Ct

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0%
7
Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 2 Pack

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 2 Pack

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0%
8
Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 3 Pack

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 3 Pack

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0%
9
Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 6 Pack

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 6 Pack

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0%
10
Prilosec OTC - 42 Tablets, Pack of 2

Prilosec OTC - 42 Tablets, Pack of 2

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0%

1. Product of Prilosec OTC 20.6mg Tablets, 42 ct. - [Bulk Savings]

Product of Prilosec OTC 20.6mg Tablets, 42 ct. - [Bulk Savings]
100%

Our Score

Prilosec OTC 20.6mg Tablets 42 count. Prilosec OTC provides 24 hours of heartburn relief for frequent heartburn that occurs 2 or more days a week. Prilosec OTC is the first and original OTC frequent heartburn medicine. It contains the active ingredient (in each tablet) Omeprazole delayed-release tablet 20mg (equivalent to 20.6mg omeprazole magnesium). Prilosec OTC is available in Original and Wildberry flavor. One pill each morning. 24 hours. Zero heartburn.

Product of Prilosec OTC 20.6mg Tablets, 42 ct. - [Bulk Savings]

2. Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea
98%

Our Score

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea UPC: 037000359074 Gtin: 00251072232930 Brand: Prilosec

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea UPC: 037000359074 Gtin: 00251072232930 Brand: Prilosec

3. Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 14 Count

Prilosec OTC Omeprazole 20mg Acid Reducer, Frequent Heartburn Medicine, Unflavored, 14 Count
94%

Our Score

With Prilosec OTC Omeprazole 20mg Unflavored Tablets 14ct, you can take control of heartburn. If you suffer from frequent heartburn, there’s no need to stash antacids everywhere for whenever heartburn might strike. With Prilosec OTC, you can take 1 PILL A DAY for 24 HOURS of ZERO HEARTBURN.* with this 24 hour acid reducer. Prilosec OTC contains omeprazole 20mg and is the first and original over-the-counter frequent heartburn (defined as occurring 2 or more times per week) medicine. The active ingredient in Prilosec OTC is omeprazole magnesium delayed-release tablet 20mg (equivalent to 20.6mg omeprazole), which is part of a class of medications called proton pump inhibitors, or PPIs. PPIs reduce stomach acid production by shutting down many of the pumps in the stomach that produce acid. In other words, Prilosec OTC 24 hour acid reducer blocks acid production at its source, so you don’t get heartburn in the first place.* Take Prilosec OTC once a day and use as directed for 14 days to treat frequent heartburn. Prilosec OTC may take 1-4 days for full effect. Prilosec OTC is the #1 Doctor†, Gastroenterologist^ and Pharmacist^^ recommended OTC frequent heartburn medicine.*It’s possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. May take 1-4 days for full effect**Confirm with insurance provider±P&G Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16.†^IQVIA ProVoice™ Survey, Jan 2005 – Mar 2020^^Pharmacy Times Surveys, Acid Reducer/Heartburn Categories 2006-2018. For adults 18 years of age and older.

Prilosec OTC TREATS FREQUENT HEARTBURN: Prilosec OTC omeprazole 20mg heartburn medicine for those who experience heartburn 2+ times a week. With just 1 PILL each morning, experience 24 HOURS with ZERO HEARTBURN With 1 PRILOSEC OTC PILL EACH MORNING, 24 HOURS. ZERO HEARTBURN.* Unlike antacids which last only 1-3 hours PREVENT EXCESS ACID PRODUCTION for heartburn relief that lasts for 24 HOURS.* Starts working on DAY 1* CONTAINS ACTIVE INGREDIENT OMEPRAZOLE delayed-release 20mg, an acid reducer that provides long-lasting, 24-hour heartburn relief* #1 DOCTOR and GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for 15 straight years^ May be HSA and FSA eligible** OVER 30 MILLION AMERICANS have used Prilosec OTC Omeprazole 20mg pills as their frequent heartburn medicine SATISFACTION GUARANTEED or your money back For adults 18 years of age and older.

4. 20pcprilosec Otc 42

20pcprilosec Otc 42
0%

Our Score

short description is not available

20pcprilosec Otc 42

5. 14pcprilosec Otc 42

14pcprilosec Otc 42
0%

Our Score

short description is not available

14pcprilosec Otc 42

6. Prilosec OTC 20.6mg Tablets, Omeprazole Magnesium, Acid Relief, Adults, 42 Ct

Prilosec OTC 20.6mg Tablets, Omeprazole Magnesium, Acid Relief, Adults, 42 Ct
0%

Our Score

Prilosec OTC is the only over-the-counter medication specifically indicated for the treatment of frequent heartburn. One pill can work for up to 24 hours to relieve frequent heartburn all day and all night.

long description is not available

7. Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 2 Pack

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 2 Pack
0%

Our Score

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 2 Pack ; UPC: 037000359074

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 2 Pack

8. Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 3 Pack

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 3 Pack
0%

Our Score

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 3 Pack ; UPC: 037000359074. Stop use and ask a doctor if your heartburn continues or worsens, you need to take this product for more than 14 days or you need to take more than 1 course of treatment every 4 months Health Concern Heartburn

Age Group: Adult Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 3 Pack ; UPC: 037000359074. Stop use and ask a doctor if your heartburn continues or worsens, you need to take this product for more than 14 days or you need to take more than 1 course of treatment every 4 months Health Concern: Heartburn Brand: Prilosec

9. Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 6 Pack

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 6 Pack
0%

Our Score

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 6 Pack ; UPC: 037000359074

Prilosec Otc Acid 20Mg Reducer Tablets - 42 Ea, 6 Pack ; UPC: 037000359074 GTIN - 00697977115334 Health concern - Heartburn

10. Prilosec OTC - 42 Tablets, Pack of 2

Prilosec OTC - 42 Tablets, Pack of 2
0%

Our Score

Prilosec OTC - 42 Tablets, Pack of 2

Prilosec OTC - 42 Tablets, Pack of 2


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