The Best Similac Routine Baby Formula (Advance, Pro-Advance, Supplementation) 2025

Updated On April 22nd, 2025

Looking for the best Similac Routine Baby Formula (Advance, Pro-Advance, Supplementation)? You aren't short of choices in 2022. The difficult bit is deciding the best Similac Routine Baby Formula (Advance, Pro-Advance, Supplementation) for you, but luckily that's where we can help. Based on testing out in the field with reviews, sells etc, we've created this ranked list of the finest Similac Routine Baby Formula (Advance, Pro-Advance, Supplementation).

Rank Product Name Score
1
Similac For Supplementation GMO-Free Liquid Toddler Formula, 12 oz Bottle (48)

Similac For Supplementation GMO-Free Liquid Toddler Formula, 12 oz Bottle (48)

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100%
2
Similac® Advance®* Powder Baby Formula with Iron, DHA, Lutein, 23.2-oz Tub

Similac® Advance®* Powder Baby Formula with Iron, DHA, Lutein, 23.2-oz Tub

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94%
3
Similac For Supplementation, 6 Bottles, Gentle, Non-GMO Infant Formula, for Breastfed Babies, with Prebiotics, Supports Brain & Eye Development, Ready to Feed, 2-fl-oz Bottle

Similac For Supplementation, 6 Bottles, Gentle, Non-GMO Infant Formula, for Breastfed Babies, with Prebiotics, Supports Brain & Ey

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92%
4
Similac Pro-Advance Infant Formula with Iron, 6 Count, 32-fl oz Bottles

Similac Pro-Advance Infant Formula with Iron, 6 Count, 32-fl oz Bottles

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88%
5
Similac Pro-Advance Powder Baby Formula, With 2′-FL HMO for Immune Support, 16 Convenient Single Packets, Pack of 4

Similac Pro-Advance Powder Baby Formula, With 2′-FL HMO for Immune Support, 16 Convenient Single Packets, Pack of 4

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88%
6
Similac Pro-Advance Infant Formula with Iron, 6 Count, 2-fl oz Bottles

Similac Pro-Advance Infant Formula with Iron, 6 Count, 2-fl oz Bottles

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88%
7
Similac Pro-Advance Infant Formula with Iron, 24 Count, 2-fl oz Bottles

Similac Pro-Advance Infant Formula with Iron, 24 Count, 2-fl oz Bottles

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88%
8
Similac Pro-Advance Baby Formula For Immune Support, With 2'-FL HMO, 4 Count Powder, 23.2-oz Tub

Similac Pro-Advance Baby Formula For Immune Support, With 2'-FL HMO, 4 Count Powder, 23.2-oz Tub

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86%
9
Similac Advance Infant Formula with Iron, 6 Count, Powder, 1.45-Pound Tub

Similac Advance Infant Formula with Iron, 6 Count, Powder, 1.45-Pound Tub

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84%
10
Similac Advance Infant Formula with Iron, Powder, 1.45-Pound Tub

Similac Advance Infant Formula with Iron, Powder, 1.45-Pound Tub

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84%

1. Similac For Supplementation GMO-Free Liquid Toddler Formula, 12 oz Bottle (48)

Similac For Supplementation GMO-Free Liquid Toddler Formula, 12 oz Bottle (48)
100%

Our Score

Similac For Supplementation is designed as a gentle introduction to formula for breastfeeding moms. This milk-based, iron-fortified, non-GMO* formula has 10% more prebiotics than Similac Advance and provides complete nutrition for your baby. Our exclusive blend of nutrients supports strong bones, digestive health, and brain, eye, and immune system development. Similac is the #1 brand chosen by parents and the first leading formula brand with no artificial growth hormones. * Ingredients not genetically engineered. Total US infant formula, all outlets as of 12/2019, Nielsen data. No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows. §in select stores, The SNAP (Supplemental Nutrition Assurance Program) name is a service mark of the U.S. Department of Agriculture. USDA does not endorse any goods, services, or enterprises.

48 BOTTLES: You get a total of 48 2-fl-oz bottles (12 4-packs) Ready-to-Feed formula GENTLE INTRO TO FORMULA: Specially designed for breastfeeding moms who choose to introduce formula PREBIOTICS FOR DIGESTIVE HEALTH: Approximately 10% more prebiotics than Similac Advance to help promote digestive health SUPPORTS BRAIN AND EYE DEVELOPMENT: Exclusive blend of DHA, lutein, and vitamin E, nutrients found in breast milk PROMOTES STRONG BONES: Palm olein oil-free fat blend for excellent calcium absorption[1,2] Accepting SNAP EBT on Grocery Pick Up§ for this Item

2. Similac® Advance®* Powder Baby Formula with Iron, DHA, Lutein, 23.2-oz Tub

Similac® Advance®* Powder Baby Formula with Iron, DHA, Lutein, 23.2-oz Tub
94%

Our Score

Similac Advance* is a nutritionally complete, milk-based, iron-fortified infant formula for baby’s first year. It has our exclusive blend of ingredients to support baby’s brain and eye development. Our no palm olein oil blend supports excellent calcium absorption. Similac was the first leading infant formula brand with no artificial growth hormones† and is the #1 infant formula brand fed in hospitals. * Not for infants or children with galactosemia. † No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows

EASY TO DIGEST: Similac® infant formulas are nutritionally complete and inspired by breast milk SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA, lutein, and vitamin E, ingredients found in breast milk that are important for helping support baby’s brain and eye development NO PALM OLEIN OIL: Designed to support excellent calcium absorption NO ARTIFICIAL GROWTH HORMONES† : Similac was the first leading infant formula brand with no artificial growth hormones. It’s also kosher and halal PREFERRED BRAND: Similac is the #1 infant formula brand fed in hospitals

3. Similac For Supplementation, 6 Bottles, Gentle, Non-GMO Infant Formula, for Breastfed Babies, with Prebiotics, Supports Brain & Eye Development, Ready to Feed, 2-fl-oz Bottle

Similac For Supplementation, 6 Bottles, Gentle, Non-GMO Infant Formula, for Breastfed Babies, with Prebiotics, Supports Brain & Eye Development, Ready to Feed, 2-fl-oz Bottle
92%

Our Score

Similac For Supplementation is designed as a gentle introduction to formula for breastfeeding moms. This milk-based, iron-fortified, non-GMO* formula has 10% more prebiotics than Similac Advance and provides complete nutrition for your baby. Our exclusive blend of nutrients supports strong bones, digestive health, and brain, eye, and immune system development. Similac is the first leading formula brand with no artificial growth hormones.‡* Ingredients not genetically engineered.† Total US infant formula, all outlets as of 12/2019, Nielsen data.‡ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.References: 1. Nelson SE, et al. J Am Coll Nutr. 1998;17(4):327-332. 2. Koo WW, et al. Pediatrics. 2003;111(5, pt 1):1017-1023.

GENTLE INTRO TO FORMULA: Specially designed for breastfeeding moms who choose to introduce formula TRUSTED FORMULA: The first leading formula brand with no artificial growth hormones† PREBIOTICS FOR DIGESTIVE HEALTH: Approximately 1% more prebiotics than Similac Advance to help promote digestive health SUPPORTS BRAIN AND EYE DEVELOPMENT: Exclusive blend of DHA, lutein, and vitamin E, nutrients found in breast milk FEEDING SUPPORT: Get live nutrition support from our Similac FeedingExpert team at 898688, 8:3 AM7 PM, ET

4. Similac Pro-Advance Infant Formula with Iron, 6 Count, 32-fl oz Bottles

Similac Pro-Advance Infant Formula with Iron, 6 Count, 32-fl oz Bottles
88%

Our Score

Similac Pro-Advance* with 2’-FL human milk oligosaccharide† (HMO) is complete nutrition designed to strengthen your baby’s immune system It has our exclusive blend of DHA, lutein, and vitamin E to help support baby’s brain and eye development.* Not for infants or children with galactosemia.† Not from human milk.§ Total US infant formula, all outlets as of 6/2020, Nielsen data.‖ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.

2’FL HMO FOR IMMUNE SUPPORT: Similac Pro-Advance has 2’FL HMO, a prebiotic that helps strengthen the immune system to be more like the breastfed infant than ever before SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA, lutein, and vitamin E, ingredients found in breast milk that are important for helping to support baby’s brain and eye development PROMOTES STRONG BONES: Has no palm olein oil to promote excellent calcium absorption for strong bones NO ARTIFICIAL GROWTH HORMONES‖ & NON-GMO¶: Similac is the first leading infant formula brand with no artificial growth hormones. Similac Pro-Advance contains ingredients that are not genetically engineered

5. Similac Pro-Advance Powder Baby Formula, With 2′-FL HMO for Immune Support, 16 Convenient Single Packets, Pack of 4

Similac Pro-Advance Powder Baby Formula, With 2′-FL HMO for Immune Support, 16 Convenient Single Packets, Pack of 4
88%

Our Score

Similac Pro-Advance* with 2′-FL human milk oligosaccharide† (HMO) is complete nutrition to help strengthen your baby’s immune system, from the #1 infant formula brand fed in hospitals. It has our exclusive blend of DHA, lutein, and vitamin E— important ingredients found in breast milk. * Not for infants or children with galactosemia. † Not from human milk. ‡ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows. § Ingredients not genetically engineered.

2′-FL HMO FOR IMMUNE SUPPORT: Similac Pro-Advance has 2′-FL HMO, a prebiotic that helps strengthen the immune system SUPPORTS BRAIN & EYES: Has DHA and lutein, important ingredients found in breast milk NO PALM OLEIN OIL: Made with no palm olein oil to support excellent calcium absorption PREFERRED BRAND: Similac is the #1 infant formula brand fed in hospitals NO ARTIFICIAL GROWTH HORMONES‡ & NON-GMO§: Similac was the first leading infant formula brand with no artificial growth hormones. Similac Pro-Advance contains ingredients that are not genetically engineered

6. Similac Pro-Advance Infant Formula with Iron, 6 Count, 2-fl oz Bottles

Similac Pro-Advance Infant Formula with Iron, 6 Count, 2-fl oz Bottles
88%

Our Score

Similac Pro-Advance* with 2’-FL human milk oligosaccharide† (HMO) is complete nutrition designed to strengthen your baby’s immune system It has our exclusive blend of DHA, lutein, and vitamin E to help support baby’s brain and eye development.* Not for infants or children with galactosemia.† Not from human milk.§ Total US infant formula, all outlets as of 6/2020, Nielsen data.‖ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.

2’FL HMO FOR IMMUNE SUPPORT: Similac Pro-Advance has 2’FL HMO, a prebiotic that helps strengthen the immune system to be more like the breastfed infant than ever before SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA, lutein, and vitamin E, ingredients found in breast milk that are important for helping to support baby’s brain and eye development PROMOTES STRONG BONES: Has no palm olein oil to promote excellent calcium absorption for strong bones NO ARTIFICIAL GROWTH HORMONES‖ & NON-GMO¶: Similac is the first leading infant formula brand with no artificial growth hormones. Similac Pro-Advance contains ingredients that are not genetically engineered

7. Similac Pro-Advance Infant Formula with Iron, 24 Count, 2-fl oz Bottles

Similac Pro-Advance Infant Formula with Iron, 24 Count, 2-fl oz Bottles
88%

Our Score

Similac Pro-Advance* with 2’-FL human milk oligosaccharide† (HMO) is complete nutrition designed to strengthen your baby’s immune system It has our exclusive blend of DHA, lutein, and vitamin E to help support baby’s brain and eye development.* Not for infants or children with galactosemia.† Not from human milk.§ Total US infant formula, all outlets as of 6/2020, Nielsen data.‖ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.

2’FL HMO FOR IMMUNE SUPPORT: Similac Pro-Advance has 2’FL HMO, a prebiotic that helps strengthen the immune system to be more like the breastfed infant than ever before SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA, lutein, and vitamin E, ingredients found in breast milk that are important for helping to support baby’s brain and eye development PROMOTES STRONG BONES: Has no palm olein oil to promote excellent calcium absorption for strong bones NO ARTIFICIAL GROWTH HORMONES‖ & NON-GMO¶: Similac is the first leading infant formula brand with no artificial growth hormones. Similac Pro-Advance contains ingredients that are not genetically engineered

8. Similac Pro-Advance Baby Formula For Immune Support, With 2'-FL HMO, 4 Count Powder, 23.2-oz Tub

Similac Pro-Advance Baby Formula For Immune Support, With 2'-FL HMO, 4 Count Powder, 23.2-oz Tub
86%

Our Score

Similac Pro-Advance* with 2’-FL human milk oligosaccharide† (HMO) is complete nutrition designed to strengthen your baby’s immune system It has our exclusive blend of DHA, lutein, and vitamin E to help support baby’s brain and eye development.* Not for infants or children with galactosemia.† Not from human milk.§ Total US infant formula, all outlets as of 6/2020, Nielsen data.‖ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.

2’-FL HMO FOR IMMUNE SUPPORT: Similac Pro-Advance has 2’-FL HMO, a prebiotic that helps strengthen the immune system to be more like the breastfed infant than ever before SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA, lutein, and vitamin E, ingredients found in breast milk that are important for helping to support baby’s brain and eye development PROMOTES STRONG BONES: Has no palm olein oil to promote excellent calcium absorption for strong bones TRUSTED BRAND: Similac is the #1 infant formula brand chosen by parents§ NO ARTIFICIAL GROWTH HORMONES‖ & NON-GMO¶: Similac is the first leading infant formula brand with no artificial growth hormones. Similac Pro-Advance contains ingredients that are not genetically engineered Accepting SNAP EBT on Grocery Pick Up| for this Item

9. Similac Advance Infant Formula with Iron, 6 Count, Powder, 1.45-Pound Tub

Similac Advance Infant Formula with Iron, 6 Count, Powder, 1.45-Pound Tub
84%

Our Score

Similac Advance* is a nutritionally complete, milk-based, iron-fortified infant formula for baby’s first year. It has our exclusive blend of ingredients to support baby’s brain and eye development. Our no palm olein oil blend promotes excellent calcium absorption for strong bones. Similac was the first leading infant formula brand with no artificial growth hormones†* Not for infants or children with galactosemia.† No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.‡ Total US infant formula, all outlets as of 6/2020, Nielsen data.

SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA, lutein, and vitamin E, ingredients found in breast milk that are important for helping support baby’s brain and eye development PROMOTES STRONG BONES: Has no palm olein oil to promote excellent calcium absorption for strong bones NO ARTIFICIAL GROWTH HORMONES†: Similac is the first leading infant formula brand with no artificial growth hormones. It’s also kosher and halal

10. Similac Advance Infant Formula with Iron, Powder, 1.45-Pound Tub

Similac Advance Infant Formula with Iron, Powder, 1.45-Pound Tub
84%

Our Score

Similac Advance* is a nutritionally complete, milk-based, iron-fortified infant formula for baby’s first year. It has our exclusive blend of ingredients to support baby’s brain and eye development. Our no palm olein oil blend promotes excellent calcium absorption for strong bones. Similac was the first leading infant formula brand with no artificial growth hormones†* Not for infants or children with galactosemia.† No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.‡ Total US infant formula, all outlets as of 6/2020, Nielsen data.

SUPPORTS BRAIN & EYE DEVELOPMENT: Features our exclusive blend of DHA, lutein, and vitamin E, ingredients found in breast milk that are important for helping support baby’s brain and eye development PROMOTES STRONG BONES: Has no palm olein oil to promote excellent calcium absorption for strong bones NO ARTIFICIAL GROWTH HORMONES†: Similac is the first leading infant formula brand with no artificial growth hormones. It’s also kosher and halal


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